Article

Functional Synergism of STAT6 with Either NF-κB or PU.1 to Mediate IL-4-Induced Activation of IgE Germline Gene Transcription

1999-10-01

Abstract excerpt

Abstract Ig heavy chain class switching to IgE is directed by IL-4 and IL-13 by inducing transcription from the IgE germline promoter. A crucial transcription factor in this process is STAT6, which binds to a specific DNA element upon cytokine activation. In this paper it is shown that the B cell- and monocyte-specific factor PU.1 interacts with a closely spaced sequence in the human IgE germline promoter that ove...

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Literature Corpus work: 544ea326-3c89-5d2a-8144-733309ecaa38
DOI: 10.4049/jimmunol.163.8.4383

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