Article

CBFα3 (AML2) Is Induced by TGF-β1 to Bind and Activate the Mouse Germline Ig α Promoter

1998-12-01

Abstract excerpt

Abstract TGF-β1 directs class switching to IgA by splenic B cells and by the surface IgM+ B cell line, I.29μ, by inducing germline (GL) Ig α transcripts. The promoter segment between −130 and +46, relative to the first initiation site for mouse GL α transcripts, is sufficient for expression and TGF-β1 inducibility of a reporter gene in B cell lines. Within this segment resides a TGF-β1-responsive element (TβRE) th...

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Literature Corpus work: 9f193f66-586d-5cc3-9d17-0517d2f081c8
DOI: 10.4049/jimmunol.161.12.6751

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