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Article

Differential Regulation of Mouse Germline Ig γ1 and ε Promoters by IL-4 and CD40

1 Aug 2001

Abstract excerpt

Before Ig class switching, RNA transcription through the specific S regions undergoing recombination is induced by cytokines and other activators that induce and direct switching. The resulting germline (GL) transcripts are essential for switch recombination. To understand the differential regulation of mouse IgG1 and IgE, we compared the promoters for GL gamma1 and epsilon transcripts. We addressed the question...

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Identifiers

PMID: 11466373
DOI: 10.4049/jimmunol.167.3.1522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Differential Regulation of Mouse Germline Ig γ1 and ε Promoters by IL-4 and CD40PMID 11466373Read ↗

Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50.Semantic proximity Read ↗

Processing of switch transcripts is required for targeting of antibody class switch recombination.Semantic proximity Read ↗

NF-kappaB elements associated with the Stat6 site in the germline gamma1 immunoglobulin promoter are not necessary for the transcriptional response to CD40 ligand.Semantic proximity Read ↗

Single nucleotide changes in the human Igamma1 and Igamma4 promoters underlie different transcriptional responses to CD40.Semantic proximity Read ↗

Analysis of the promoter elements necessary for IL-4 and anti-CD40 antibody induction of murine Fc epsilon RII (CD23): comparison with the germline epsilon promoter.Semantic proximity Read ↗

Switch Transcripts in Immunoglobulin Class SwitchingSemantic proximity Read ↗

Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.Semantic proximity Read ↗

CBFα3 (AML2) Is Induced by TGF-β1 to Bind and Activate the Mouse Germline Ig α PromoterSemantic proximity Read ↗

Elucidation of IgH 3′ region regulatory role during class switch recombination via germline deletionSemantic proximity Read ↗

Roles of the Ig κ Light Chain Intronic and 3′ Enhancers in Igk Somatic HypermutationSemantic proximity Read ↗

S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.Semantic proximity Read ↗

Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination.Semantic proximity Read ↗

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