Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single nucleotide changes in the human Igamma1 and Igamma4 promoters underlie different transcriptional responses to CD40.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2009

Sinquett Frank L, Dryer Rebecca L, Marcelli Valentina, Batheja Ameesha, Covey Lori R

Abstract excerpt

Analysis of subclass-specific germline transcription in activated peripheral B cells revealed a highly biased expression pattern of the four Igamma transcripts to signals through CD40 and IL-4. This difference was most pronounced when comparing the profile of Igamma1 and Igamma4 transcripts and was not expected given the very high degree of sequence conservation between promoters. In this report, the influence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to CD40 Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Electrophoretic Mobility Shift Assay

Share to Genes, Immunoglobulin

Share to Immunoglobulin G

Share to Mutagenesis, Site-Directed

Share to NF-kappa B

Share to Oligonucleotide Array Sequence Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 19201872
DOI: 10.4049/jimmunol.0802700
PMCID: PMC2701896

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single nucleotide changes in the human Igamma1 and Igamma4 promoters underlie different transcriptional responses to CD40.PMID 19201872Read ↗

Differential Regulation of Mouse Germline Ig γ1 and ε Promoters by IL-4 and CD40Semantic proximity Read ↗

Inhibition of p65 NF-κB enhances production of galactose-deficient IgA1 through suppression of C1GALT1 and SP1 in plasmablast-like cell subpopulationsSemantic proximity Read ↗

The human I alpha 1 and I alpha 2 germline promoter elements: proximal positive and distal negative elements may regulate the tissue specific expression of C alpha 1 and C alpha 2 germline transcripts.Semantic proximity Read ↗

Analysis of the promoter elements necessary for IL-4 and anti-CD40 antibody induction of murine Fc epsilon RII (CD23): comparison with the germline epsilon promoter.Semantic proximity Read ↗

Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells.Semantic proximity Read ↗

Monogenic mutations associated with IgA deficiency.Semantic proximity Read ↗

Promoter region architecture and transcriptional regulation of the genes for the MHC class I-related chain A and B ligands of NKG2D.Semantic proximity Read ↗

Allele *1 of HS1.2 enhancer associates with selective IgA deficiency and IgM concentration.Semantic proximity Read ↗

Polymorphisms in the Paan-AG promoter influence NF-kappaB binding and transcriptional activity.Semantic proximity Read ↗

Conserved residues of the bare lymphocyte syndrome transcription factor RFXAP determine coordinate MHC class II expression.Semantic proximity Read ↗

NF-kappaB elements associated with the Stat6 site in the germline gamma1 immunoglobulin promoter are not necessary for the transcriptional response to CD40 ligand.Semantic proximity Read ↗

Alleles of the alpha1 immunoglobulin gene 3' enhancer control evolution of IgA nephropathy toward renal failure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.