Article
Hyperactivation and proliferation of lymphocytes from the spleens of flaky skin (fsn) mutant mice.
Autoimmunity - 1 May 2004
Welner Robert, Hastings William, Hill Beth L, Pelsue Stephen C
Abstract excerpt
Mice homozygous for the flaky skin (fsn) single gene mutation have a severe hyperproliferative disease resulting in a complex phenotype, which includes widespread inflammation and autoimmunity. This study sought to characterize lymphocyte function of flaky skin mutant mice. Flaky skin lymphocytes show enhanced proliferation with in vitro mitogen stimulated spleen cells, as well as enriched splenic B- and T-cells....
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