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The Tetratricopeptide repeat domain 7 gene is mutated in flaky skin mice: a model for psoriasis, autoimmunity, and anemia.

Experimental biology and medicine (Maywood, N.J.) - 1 Oct 2005

Helms Cynthia, Pelsue Stephen, Cao Li, Lamb Erika, Loffredo Brett, Taillon-Miller Patricia, Herrin Brooke, Burzenski Lisa M, Gott Bruce, Lyons Bonnie L, Keppler Deana, Shultz Leonard D, Bowcock Anne M

Abstract excerpt

The flaky skin (fsn) mutation in mice causes pleiotropic abnormalities including psoriasiform dermatitis, anemia, hyper-IgE, and anti-dsDNA autoantibodies resembling those detected in systemic lupus erythematosus. The fsn mutation was mapped to an interval of 3.9 kb on chromosome 17 between D17Mit130 and D17Mit162. Resequencing of known and predicted exons and regulatory sequences from this region in fsn/fsn and...

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Source

Identifiers

PMID: 16179734
DOI: 10.1177/153537020523000908

Genes

TPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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