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Article

Thymic stromal lymphopoietin contributes to myeloid hyperplasia and increased immunoglobulins, but not epidermal hyperplasia, in RabGEF1-deficient mice.

The American journal of pathology - 1 Nov 2010

Tsai Mindy, Chen Ching-Cheng, Mukai Kaori, Song Chang Ho, Thompson Lucas J, Ziegler Steven F, Tam See-Ying, Galli Stephen J

Abstract excerpt

Mice overexpressing the proallergic cytokine thymic stromal lymphopoietin (TSLP) in the skin develop a pathology resembling atopic dermatitis. RabGEF1, a guanine nucleotide exchange factor for Rab5 GTPase, is a negative regulator of IgE-dependent mast cell activation, and Rabgef1-/- and TSLP tran...

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Source

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Identifiers

PMID: 20829437
DOI: 10.2353/ajpath.2010.100181
PMCID: PMC2966799

Genes

TSLP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20829437-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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