Article
Genetic analysis of the CD28/CTLA4/ICOS (CELIAC3) region in coeliac disease.
Tissue antigens - 1 Nov 2004
Amundsen S S, Naluai A T, Ascher H, Ek J, Gudjónsdóttir A H, Wahlström J, Lie B A, Sollid L M
Abstract excerpt
In order to extend our previous findings of genetic linkage to the CD28/CTLA4/ICOS region on chromosome 2q33 (CELIAC3) in coeliac disease (CD), we have investigated 22 genetic markers in 325 Norwegian/Swedish multiplex and simplex CD families. We found both linkage and association with several markers, primarily in the multiplex material. We observed strong linkage disequilibrium (LD) between SNPs (Single...
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