Article
Mutational analysis of CD28 in coeliac disease.
Scandinavian journal of gastroenterology - 1 May 2002
Popat S, Hearle N, Bevan S, Hogberg L, Stenhammar L, Houlston R S
Abstract excerpt
BACKGROUND: Coeliac disease shows a strong genetic predisposition involving HLA-DQ2 and non-HLA components. The CD28 cell surface molecule, encoded by CD28, represents a potential candidate coeliac disease susceptibility gene. Furthermore, some studies have demonstrated linkage to the CD28/CTLA4 gene region. To investigate whether germline mutations in CD28 contribute to coeliac disease susceptibility, we have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.