Article
Haplotypes in the CTLA4 region are associated with coeliac disease in the Irish population.
Genes and immunity - 1 Jan 2006
Brophy K, Ryan A W, Thornton J M, Abuzakouk M, Fitzgerald A P, McLoughlin R M, O'morain C, Kennedy N P, Stevens F M, Feighery C, Kelleher D, McManus R
Abstract excerpt
Chromosomal region 2q33 encodes the immune regulatory genes, CTLA4, ICOS and CD28, which are involved in regulation of T-cell activity and has been studied as a candidate gene locus in autoimmune diseases, including coeliac disease (CD). We have investigated whether an association exists between...
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