Article
Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study.
BMC medical genetics - 17 May 2010
Brophy Karen, Ryan Anthony W, Turner Graham, Trimble Valerie, Patel Kunal D, O'Morain Colm, Kennedy Nicholas P, Egan Brian, Close Eimear, Lawlor Garrett, MacMathuna Padraic, Stevens Fiona M, Abuzakouk Mohamed, Feighery Conleth, Kelleher Dermot, McManus Ross
Abstract excerpt
BACKGROUND: Recent whole genome analysis and follow-up studies have identified many new risk variants for coeliac disease (CD, gluten intolerance). The majority of newly associated regions encode candidate genes with a clear functional role in T-cell regulation. Furthermore, the newly discovered risk loci, together with the well established HLA locus, account for less than 50% of the heritability of CD,...
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