Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inverse relationship between increased apoptosis and decreased skin cancer in UV-irradiated CD1d-/- mice.

Photochemistry and photobiology - 1 Jan 2000

Matsumura Yasuhiro, Moodycliffe Angus M, Nghiem Dat X, Ullrich Stephen E, Ananthaswamy Honnavara N

Abstract excerpt

We previously demonstrated that CD1d knockout mice were resistant to ultraviolet (UV)-induced immunosuppression. Because immune suppression is a critical factor in the development of UV-induced skin cancers, we investigated the response of wild type (WT) and CD1d-/- mice to UV carcinogenesis. We found that although 100% of WT mice developed skin tumors after 45 weeks of UV irradiation, only 60% of CD1d-/- mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD1
Share to Antigens, CD1d

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apoptosis

Share to Genes, p53

Share to Mice, Knockout

Share to Neoplasms, Radiation-Induced

Share to Skin Neoplasms

Share to Ultraviolet Rays

Source

Identifiers

PMID: 15496135
DOI: 10.1562/2004-09-21-IR-322

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inverse relationship between increased apoptosis and decreased skin cancer in UV-irradiated CD1d-/- mice.PMID 15496135Read ↗

Resistance of CD1d-/- mice to ultraviolet-induced skin cancer is associated with increased apoptosis.Semantic proximity Read ↗

Absence of full-length Brca1 sensitizes mice to oxidative stress and carcinogen-induced tumorigenesis in the esophagus and forestomach.Semantic proximity Read ↗

Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice.Semantic proximity Read ↗

Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence.Semantic proximity Read ↗

Differential Roles of T‐cell Subsets in Regulation of Ultraviolet Radiation Induced Cutaneous PhotocarcinogenesisSemantic proximity Read ↗

Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53.Semantic proximity Read ↗

UVB-induced Senescence in Human Keratinocytes Requires a Functional Insulin-like Growth Factor-1 Receptor and p53Semantic proximity Read ↗

Mouse Rad1 deletion enhances susceptibility for skin tumor development.Semantic proximity Read ↗

CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice.Semantic proximity Read ↗

Loss of Fas-ligand expression in mouse keratinocytes during UV carcinogenesis.Semantic proximity Read ↗

p38 MAP kinase plays a functional role in UVB‐Induced mouse skin carcinogenesisSemantic proximity Read ↗

Fate of UVB-induced p53 mutations in SKH-hr1 mouse skin after discontinuation of irradiation: relationship to skin cancer development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.