Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fate of UVB-induced p53 mutations in SKH-hr1 mouse skin after discontinuation of irradiation: relationship to skin cancer development.

Oncogene - 27 Oct 2005

Melnikova Vladislava O, Pacifico Alessia, Chimenti Sergio, Peris Ketty, Ananthaswamy Honnavara N

Abstract excerpt

Chronic exposure to ultraviolet (UV) radiation causes skin cancer in humans and mice. We have previously shown that in hairless SKH-hr1 mice, UVB-induced p53 mutations arise very early, well before tumor development. In this study, we investigated whether discontinuation of UVB exposure before the onset of skin tumors results in the disappearance of p53 mutations in the skin of hairless SKH-hr1 mice. Irradiation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Keratinocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Hairless

Share to Neoplasms, Radiation-Induced

Share to Skin Neoplasms

Share to Tumor Suppressor Protein p53

Share to Ultraviolet Rays

Source

Identifiers

PMID: 16007135
DOI: 10.1038/sj.onc.1208863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fate of UVB-induced p53 mutations in SKH-hr1 mouse skin after discontinuation of irradiation: relationship to skin cancer development.PMID 16007135Read ↗

Patches of mutant p53-immunoreactive epidermal cells induced by chronic UVB Irradiation harbor the same p53 mutations as squamous cell carcinomas in the skin of hairless SKH-1 mice.Semantic proximity Read ↗

p53 Mutations in hairless SKH-hr1 mouse skin tumors induced by a solar simulator.Semantic proximity Read ↗

The absence of Brm exacerbates photocarcinogenesis.Semantic proximity Read ↗

p53 mutations in cutaneous lesions induced in the hairless mouse by a solar ultraviolet light simulator.Semantic proximity Read ↗

Effect of administration of caffeine or green tea on the mutation profile in the p53 gene in early mutant p53-positive patches of epidermal cells induced by chronic UVB-irradiation of hairless SKH-1 mice.Semantic proximity Read ↗

Relationship between UV-induced mutant p53 patches and skin tumours, analysed by mutation spectra and by induction kinetics in various DNA-repair-deficient mice.Semantic proximity Read ↗

Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells.Semantic proximity Read ↗

Low incidence of p53 mutations in UVA (365-nm)-induced skin tumors in hairless mice.Semantic proximity Read ↗

Loss of Fas-ligand expression in mouse keratinocytes during UV carcinogenesis.Semantic proximity Read ↗

Frequent p53 alterations but low incidence of ras mutations in UV-B-induced skin tumors of hairless miceSemantic proximity Read ↗

The role of UV-B light in skin carcinogenesis through the analysis of p53 mutations in squamous cell carcinomas of hairless miceSemantic proximity Read ↗

Inhibition of UV-induced p53 mutations by sunscreens: implications for skin cancer prevention.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.