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Article

Mouse Rad1 deletion enhances susceptibility for skin tumor development.

Molecular cancer - 24 Mar 2010

Han Lu, Hu Zhishang, Liu Yuheng, Wang Xiangyuan, Hopkins Kevin M, Lieberman Howard B, Hang Haiying

Abstract excerpt

BACKGROUND: Cells are constantly exposed to stresses from cellular metabolites as well as environmental genotoxins. DNA damage caused by these genotoxins can be efficiently fixed by DNA repair in cooperation with cell cycle checkpoints. Unrepaired DNA lesions can lead to cell death, gene mutation and cancer. The Rad1 protein, evolutionarily conserved from yeast to humans, exists in cells as monomer as well as a...

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Identifiers

PMID: 20334655
DOI: 10.1186/1476-4598-9-67
PMCID: PMC2864214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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