Article
CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice.
Cancer prevention research (Philadelphia, Pa.) - 1 Jan 2012
Kim Eun-Hee, Deng Chuxia, Sporn Michael B, Royce Darlene B, Risingsong Renee, Williams Charlotte R, Liby Karen T
Abstract excerpt
The breast cancer-associated gene 1 (BRCA1) is the most frequently mutated tumor suppressor gene in familial breast cancers. Mutations in BRCA1 also predispose to other types of cancers, pointing to a fundamental role of this pathway in tumor suppression and emphasizing the need for effective chemoprevention in these high-risk patients. Because the methyl ester of the synthetic triterpenoid...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.