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Article

Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53.

The Journal of clinical investigation - 1 Oct 2001

Grossman D, Kim P J, Blanc-Brude O P, Brash D E, Tognin S, Marchisio P C, Altieri D C

Abstract excerpt

The inhibitor of apoptosis protein survivin has been implicated in both cell cycle control and apoptosis resistance. To discriminate between these different roles, we used transgenic expression of survivin in the skin as a model for cell proliferation, differentiation, and apoptosis. Transgenic mice expressing survivin under the control of a keratin-14 promoter developed normally, without histologic abnormalities...

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Identifiers

PMID: 11581300
DOI: 10.1172/JCI13345
PMCID: PMC200956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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