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Article

A gene encoding a putative tyrosine phosphatase suppresses lethality of an N-end rule-dependent mutant.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1992

Ota I M, Varshavsky A

Abstract excerpt

The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. In the yeast Saccharomyces cerevisiae, mutational inactivation of the N-end rule pathway is neither lethal nor phenotypically conspicuous. We have used a "synthetic lethal" screen to isolate a mutant that requires the N-end rule pathway for viability. An extragenic suppressor of this mutation was cloned and found...

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Identifiers

PMID: 1549598
DOI: 10.1073/pnas.89.6.2355
PMCID: PMC48656

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