The recognition component of the N-end rule pathway.

doi:10.1002/j.1460-2075.1990.tb07516.x

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Article

The recognition component of the N-end rule pathway.

The EMBO journal - 1 Oct 1990

Bartel B, Wünning I, Varshavsky A

Abstract excerpt

The N-end rule-based degradation signal, which targets a protein for ubiquitin-dependent proteolysis, comprises a destabilizing amino-terminal residue and a specific internal lysine residue. We report the isolation and functional analysis of a gene (UBR1) for the N-end recognizing protein of the yeast Saccharomyces cerevisiae. UBR1 encodes a approximately 225 kd protein with no significant sequence similarities...

Topics

Amino Acid Sequence
Base Sequence
Cloning, Molecular
DNA, Fungal
Fungal Proteins
Genes, Fungal
Genotype
Ligases
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Restriction Mapping

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Substrate Specificity

Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 2209542
DOI: 10.1002/j.1460-2075.1990.tb07516.x
PMCID: PMC552047

Genes

UBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2209542-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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