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Article

Temperature sensitive nop2 alleles defective in synthesis of 25S rRNA and large ribosomal subunits in Saccharomyces cerevisiae.

Nucleic acids research - 15 Jul 2001

Hong B, Wu K, Brockenbrough J S, Wu P, Aris J P

Abstract excerpt

Using molecular genetic techniques, we have generated and characterized six temperature sensitive (ts) alleles of nop2. All failed to support growth at 37 degrees C and one was also formamide sensitive (fs) and failed to grow on media containing 3% formamide. Conditional lethality is not due to rapid turnover of mutant Nop2p proteins at 37 degrees C. Each allele contains between seven and 14 amino acid...

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Identifiers

PMID: 11452018
DOI: 10.1093/nar/29.14.2927
PMCID: PMC55797

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