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Article

A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo.

Genes & development - 1 Sept 2003

Fellner Thomas, Lackner Daniel H, Hombauer Hans, Piribauer Patrick, Mudrak Ingrid, Zaragoza Katrin, Juno Claudia, Ogris Egon

Abstract excerpt

Protein phosphatase 2A (PP2A) is an essential intracellular serine/threonine phosphatase containing a catalytic subunit that possesses the potential to dephosphorylate promiscuously tyrosine-phosphorylated substrates in vitro. How PP2A acquires its intracellular specificity and activity for serine/threonine-phosphorylated substrates is unknown. Here we report a novel and phylogenetically conserved mechanism to...

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Identifiers

PMID: 12952889
DOI: 10.1101/gad.259903
PMCID: PMC196455

Genes

PTPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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