Article
The N-end rule pathway is required for import of histidine in yeast lacking the kinesin-like protein Cin8p.
Current genetics - 1 Sept 1999
Xie Y, Varshavsky A
Abstract excerpt
The N-end rule pathway is a ubiquitin-dependent proteolytic system whose targets include proteins bearing destabilizing N-terminal residues. We carried out a synthetic lethal screen for Saccharomyces cerevisiae mutants that require the N-end rule pathway for cell viability. A mutant thus identified, termed sln2, could not grow in the absence of Ubr1p, the recognition component of the N-end rule pathway, which was...
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