Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic evidence that zinc is an essential co-factor in the DNA binding domain of GAL4 protein.

Nature - 1 Jan 2000

Johnston M

Abstract excerpt

The 'cysteine-zinc DNA binding finger' is a recently identified sequence motif that is present in a wide variety of transcriptional regulatory proteins and is thought to be directly involved in DNA binding. It has been proposed that an essential component of this structure is a zinc ion bound between two pairs of cysteine residues. The GAL4-encoded protein of Saccharomyces cerevisiae, which binds to DNA and...

Topics

Chlorides
DNA-Binding Proteins
Fungal Proteins
Genes
Genes, Fungal
Kinetics
Mutation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Transcription Factors
Zinc
Zinc Compounds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 3299106
DOI: 10.1038/328353a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3299106-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic evidence that zinc is an essential co-factor in the DNA binding domain of GAL4 protein.PMID 3299106Read ↗

Motifs in the histone H3 and H4 and chromatin modifying factors are crucial to regulate the multifactorial zinc response pathway in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cloning of a novel gene encoding a C2H2 zinc finger protein that alleviates sensitivity to abiotic stresses in Aspergillus nidulans.Semantic proximity Read ↗

A dual role for zinc fingers in both DNA binding and zinc sensing by the Zap1 transcriptional activator.Semantic proximity Read ↗

Regulation of zinc homeostasis in yeast by binding of the ZAP1 transcriptional activator to zinc-responsive promoter elements.Semantic proximity Read ↗

GAL4 mutations that separate the transcriptional activation and GAL80-interactive functions of the yeast GAL4 protein.Semantic proximity Read ↗

A role for hydrogen bonding in DNA recognition by the non-classical CCHHC type zinc finger, NZF-1.Semantic proximity Read ↗

Mutations in the bZIP domain of yeast GCN4 that alter DNA-binding specificity.Semantic proximity Read ↗

Substitution of DNA-contacting amino acids with functional variants in the Gata-1 zinc finger: a structurally and phylogenetically guided mutagenesis.Semantic proximity Read ↗

A mutation in the Zn-finger of the GAL4 homolog LAC9 results in glucose repression of its target genes.Semantic proximity Read ↗

Zinc-regulated genes in Saccharomyces cerevisiae revealed by transposon tagging.Semantic proximity Read ↗

Two zinc fingers of a yeast regulatory protein shown by genetic evidence to be essential for its function.Semantic proximity Read ↗

Site-selective in vivo targeting of cytosine-5 DNA methylation by zinc-finger proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.