Article
Genetic evidence that zinc is an essential co-factor in the DNA binding domain of GAL4 protein.
Nature - 1 Jan 2000
Johnston M
Abstract excerpt
The 'cysteine-zinc DNA binding finger' is a recently identified sequence motif that is present in a wide variety of transcriptional regulatory proteins and is thought to be directly involved in DNA binding. It has been proposed that an essential component of this structure is a zinc ion bound between two pairs of cysteine residues. The GAL4-encoded protein of Saccharomyces cerevisiae, which binds to DNA and...
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