Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelial nitric oxide synthase gene polymorphism, homocysteine, cholesterol and vascular endothelial function.

Atherosclerosis - 1 Jul 2003

Bilsborough William, Green Daniel J, Mamotte Cyril D S, van Bockxmeer Frank M, O'Driscoll Gerard J, Taylor Roger R

Abstract excerpt

Nitric oxide-dependent vasodilation is impaired early in the pathogenesis of vascular disease. Both the 4ab polymorphism of endothelial nitric oxide synthase (eNOS) and elevated plasma homocysteine are putatively associated with coronary artery disease (CAD). Few studies have investigated the influence of either on endothelial function in normal subjects. We aimed to examine any effect of three eNOS gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brachial Artery
Share to Folic Acid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homocysteine

Share to Nitric Oxide

Share to Nitric Oxide Synthase

Share to Nitric Oxide Synthase Type III

Share to Ultrasonography

Share to Vasodilation

Source

Identifiers

PMID: 12860259
DOI: 10.1016/s0021-9150(03)00147-3

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelial nitric oxide synthase gene polymorphism, homocysteine, cholesterol and vascular endothelial function.PMID 12860259Read ↗

Hyperhomocysteinemia, vascular pathology, and endothelial dysfunction.Semantic proximity Read ↗

Endothelial nitric oxide synthase -786T>C, but not 894G>T and 4a4b, polymorphism influences plasma homocysteine concentrations in persons with normal vitamin status.Semantic proximity Read ↗

Endothelial nitric oxide synthase and methylenetetrahydrofolate reductase gene polymorphisms are associated with endothelial dysfunction in young, healthy men.Semantic proximity Read ↗

Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function.Semantic proximity Read ↗

Influence of methylenetetrahydrofolate reductase genotype, exercise and other risk factors on endothelial function in healthy individuals.Semantic proximity Read ↗

Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh Artery Study.Semantic proximity Read ↗

A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene.Semantic proximity Read ↗

The functional consequence of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in young healthy volunteers.Semantic proximity Read ↗

Endothelium function biomarkers and carotid intima-media thickness changes in relation to NOS3 (rs2070744) and GNB3 (rs5443) genes polymorphism in the essential arterial hypertensionSemantic proximity Read ↗

Endothelial Function and Carotid Intima-Media Thickness in Young Healthy Subjects Among Endothelial Nitric Oxide Synthase Glu <sup>298</sup> →Asp and T <sup>−786</sup> →C PolymorphismsSemantic proximity Read ↗

Optimization of dietary folate or low-dose folic acid supplements lower homocysteine but do not enhance endothelial function in healthy adults, irrespective of the methylenetetrahydrofolate reductase (C677T) genotype.Semantic proximity Read ↗

Low folate levels may be an atherogenic factor regardless of homocysteine levels in young healthy nonsmokers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.