Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influence of methylenetetrahydrofolate reductase genotype, exercise and other risk factors on endothelial function in healthy individuals.

Clinical science (London, England : 1979) - 1 Jan 2002

Pullin Catherine H, Wilson John F, Ashfield-Watt Pauline A L, Clark Zoë E, Whiting Jenny M, Lewis Malcolm J, McDowell Ian F W

Abstract excerpt

Cardiovascular disease has a multifactorial aetiology that is influenced by both genetic and environmental factors. Endothelial dysfunction is a key event in the pathogenesis of vascular disease that occurs before structural vascular changes or clinical symptoms are evident. Conventional risk factors, for example hypertension and diabetes mellitus, are associated with endothelial dysfunction, but the influence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endothelium, Vascular
Share to Estrogen Replacement Therapy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Exercise

Share to Homocysteine

Share to Normal Distribution

Share to Oxidoreductases Acting on CH-NH Group Donors

Share to Regional Blood Flow

Share to Ultrasonography

Source

Identifiers

PMID: 11749660

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of methylenetetrahydrofolate reductase genotype, exercise and other risk factors on endothelial function in healthy individuals.PMID 11749660Read ↗

Endothelial nitric oxide synthase gene polymorphism, homocysteine, cholesterol and vascular endothelial function.Semantic proximity Read ↗

Low folate levels may be an atherogenic factor regardless of homocysteine levels in young healthy nonsmokers.Semantic proximity Read ↗

Associations of methylenetetrahydrofolate reductase C677T polymorphism with markers of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study.Semantic proximity Read ↗

Endothelial nitric oxide synthase and methylenetetrahydrofolate reductase gene polymorphisms are associated with endothelial dysfunction in young, healthy men.Semantic proximity Read ↗

Optimization of dietary folate or low-dose folic acid supplements lower homocysteine but do not enhance endothelial function in healthy adults, irrespective of the methylenetetrahydrofolate reductase (C677T) genotype.Semantic proximity Read ↗

Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis.Semantic proximity Read ↗

Endothelium-dependent vasodilation is impaired in apparently healthy subjects with a family history of myocardial infarction.Semantic proximity Read ↗

Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh Artery Study.Semantic proximity Read ↗

Peripheral arterial disease and methylenetetrahydrofolate reductase (MTHFR) C677T mutations: A case-control study and meta-analysis.Semantic proximity Read ↗

Association of methylenetetrahydrofolate reductase gene polymorphism with carotid arterial wall thickening and myocardial infarction risk in NIDDM.Semantic proximity Read ↗

Hyperhomocysteinemia, vascular pathology, and endothelial dysfunction.Semantic proximity Read ↗

An association between the methylenetetrahydrofolate reductase (MTHFR) C677T mutation and inflammation markers related to cardiovascular disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.