The importance of genome architecture in cancer susceptibility: location, location, location.

doi:10.4161/cc.3.11.1253

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The importance of genome architecture in cancer susceptibility: location, location, location.

Cell cycle (Georgetown, Tex.) - 1 Nov 2004

Reilly Karlyne M

Abstract excerpt

Tumorigenesis requires the interaction between different gene disruptions to convert a normal cell into a cancer cell. These gene disruptions can involve loss of expression or misexpression of genes through genetic or epigenetic mutations. It is becoming clear that these disruptions are not isolated events in the genome, but are affected by genome architecture and the syntenic relationship of alleles on...

Topics

Animals
Astrocytoma
Cell Transformation, Neoplastic
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Gene Silencing
Genetic Predisposition to Disease
Genome, Human
Genomic Imprinting
Humans
Mice
Models, Genetic
Mutation
Neurofibromin 1
Species Specificity
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 15492507
DOI: 10.4161/cc.3.11.1253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics