The importance of genome architecture in cancer susceptibility: location, location, location.

Abstract excerpt

Tumorigenesis requires the interaction between different gene disruptions to convert a normal cell into a cancer cell. These gene disruptions can involve loss of expression or misexpression of genes through genetic or epigenetic mutations. It is becoming clear that these disruptions are not isolated events in the genome, but are affected by genome architecture and the syntenic relationship of alleles on...

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