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Article

Genetic determinants of malignancy in a mouse model for oligodendroglioma.

Cancer research - 1 Apr 2003

Weiss William A, Burns Michael J, Hackett Christopher, Aldape Ken, Hill John R, Kuriyama Hiroko, Kuriyama Nagato, Milshteyn Nadezhda, Roberts Tim, Wendland Michael F, DePinho Ron, Israel Mark A

Abstract excerpt

Oligodendrogliomas of all grades overexpress epidermal growth factor receptor (EGFR), whereas deletion of ink4a/arf is found only in high-grade tumors. We used the S100 beta promoter to generate transgenic mice expressing v-erbB, a transforming allele of EGFR. These mice developed low-grade oligo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12670909

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12670909-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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