Article
Molecular genetics of human cancer predisposition and progression.
Mutation research - 1 Apr 1991
Cavenee W K, Scrable H J, James C D
Abstract excerpt
The development of human cancer is generally thought to entail a series of events that cause a progressively more malignant phenotype. Such a hypothesis predicts that tumor cells of the ultimate stage will carry each of the events, cells of the penultimate stage will carry each of the events less the last one and so on. A dissection of the pathway from a normal cell to a fully malignant tumor may thus be viewed...
Topics
- Astrocytoma
- Chromosome Deletion
- Genes, Retinoblastoma
- Genotype
- Heterozygote
- Humans
- Neoplasms