Article
Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects.
Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 2004
Reilly Karlyne M, Tuskan Robert G, Christy Emily, Loisel Dagan A, Ledger Jeremy, Bronson Roderick T, Smith C Dahlem, Tsang Shirley, Munroe David J, Jacks Tyler
Abstract excerpt
Astrocytoma is the most common malignant brain tumor in humans. Loss of the p53 signaling pathway and up-regulation of the ras signaling pathway are common during tumor progression. We have shown previously that mice mutant for Trp53 and Nf1 develop astrocytoma, progressing to glioblastoma, on a C57BL/6J strain background. In contrast, here we present data that mice mutant for Trp53 and Nf1 on a 129S4/SvJae...
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