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Article

An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model.

Cancer research - 1 Jan 2006

Reilly Karlyne M, Broman Karl W, Bronson Roderick T, Tsang Shirley, Loisel Dagan A, Christy Emily S, Sun Zhonghe, Diehl John, Munroe David J, Tuskan Robert G

Abstract excerpt

Cancer is a complex disease in which cells acquire many genetic and epigenetic alterations. We have examined how three types of alterations, mutations in tumor suppressor genes, changes in an imprinted locus, and polymorphic loci, interact to affect tumor susceptibility in a mouse model of neurofibromatosis type 1 (NF1). Mutations in tumor suppressor genes such as TP53 and in oncogenes such as KRAS have major...

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Share to Epigenesis, Genetic
Share to Genes, Neurofibromatosis 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

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Share to Mice, Inbred C57BL

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Source

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Identifiers

PMID: 16397217
DOI: 10.1158/0008-5472.CAN-05-1480
PMCID: PMC1401492

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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