Epigenetics and cancer without genomic instability

Abstract excerpt

Genomic instability is often considered a hallmark of cancer. However, it remains unclear whether chromosomal disorganization is most frequently a cause or a consequence of tumorigenesis. The fact that subsets of many cancers lack chromosomal or microsatellite instability argues against the hypothesis that genomic instability plays an essential role in the initiation and maintenance of oncogenesis....

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