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Article

Accumulation of genetic defects during astrocytoma progression.

Cancer - 15 Sept 1992

Cavenee W K

Abstract excerpt

BACKGROUND: The development of human cancer generally is thought to entail a series of events that cause a progressively more malignant phenotype. This hypothesis predicts that tumor cells of the ultimate stage will carry each of the events; cells of the penultimate stage will carry each of the events minus the last one; and so on. Therefore, a dissection of the pathway from a normal cell to a fully malignant...

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PMID: 1325281
DOI: 10.1002/1097-0142(19920915)70:4+<1788::aid-cncr2820701621>3.0.co;2-l

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