Evolution of Esophageal Adenocarcinoma From Precursor Lesion Stem Cells.

doi:10.1053/j.gastro.2025.02.032

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Evolution of Esophageal Adenocarcinoma From Precursor Lesion Stem Cells.

Gastroenterology - 1 Aug 2025

Xian Wa, Wang Shan, Xie Jingzhong, Yamamoto Yusuke, Khorrami Melina, Zhang Yanting, Montes Raul Caballero, Desales Caycel, Khorrami Melika, Mory Zaal, Hoffman Ashley, Su Amber, Nguyen Crystal, Davies Peter J A, Stephan Clifford, Pan Shuang, Wu Wengen, Liu Yuxin, Siegelman Jeremy, Waters Rebecca E, Ross William A, Song Shumei, Metersky Mark, Beer David G, Crum Christopher P, Stewart Alexander J, Vincent Matthew, Russell Richard, Izard Robert A, Ho Khek Yu, Hung-Sen Lai Jack, Bachovchin William W, Ajani Jaffer A, McKeon Frank D

Abstract excerpt

BACKGROUND & AIMS: Metastatic cancers arise from a decades-long succession of increasingly virulent precursor lesions, each of which represents prospective targets for therapeutic intervention. This evolutionary process has been particularly vivid in esophageal adenocarcinoma (EAC), as this cancer and associated precursor lesions, including Barrett's esophagus (BE), low-grade dysplasia (LGD), and high-grade...

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PMID: 40090599
DOI: 10.1053/j.gastro.2025.02.032
PMCID: PMC12289430

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