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Article

ZBED2 is an antagonist of interferon regulatory factor 1 and modifies cell identity in pancreatic cancer

8 May 2020

Abstract excerpt

Lineage plasticity is a prominent feature of pancreatic ductal adenocarcinoma (PDA) cells, which can occur via deregulation of lineage-specifying transcription factors. Here, we show that the zinc finger protein ZBED2 is aberrantly expressed in PDA and alters tumor cell identity in this disease. Unexpectedly, our epigenomic experiments reveal that ZBED2 is a sequence-specific transcriptional repressor of...

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Share to Epigenetics and DNA Methylation
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PMID: 32385160
DOI: 10.1073/pnas.1921484117

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