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Article

Id2 deficiency promotes metastasis in a mouse model of ocular cancer.

Clinical & experimental metastasis - 1 Feb 2010

Agapova Olga A, Person Erica, Harbour J William

Abstract excerpt

The inhibitor of DNA binding 2 (Id2) basic helix-loop-helix protein interacts genetically and physically with the pocket proteins (Rb, p107 and p130) and has been implicated as an oncogene. In other studies, however, Id2 has been shown to function as a tumor suppressor. Here, we studied the role of Id2 in a well characterized model of ocular cancer in which the three pocket proteins are inactivated by generating...

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Identifiers

PMID: 20127274
DOI: 10.1007/s10585-010-9304-5
PMCID: PMC4467556

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Id2 deficiency promotes metastasis in a mouse model of ocular cancer.PMID 20127274Read ↗

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