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NDRG2 facilitates colorectal cancer differentiation through the regulation of Skp2-p21/p27 axis

15 Jan 2018

Abstract excerpt

Poorly differentiated colorectal cancers (CRCs) are more aggressive and lack targeted therapies. We and others previously reported the predominant role of tumor-suppressor NDRG2 in promoting CRC differentiation, but the underlying mechanism is largely unknown. Herein, we demonstrate that NDRG2 induction of CRC cell differentiation is dependent on the repression of E3 ligase Skp2 activity. In patients and Ndrg2...

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PMID: 29343851
DOI: 10.1038/s41388-017-0118-7

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