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Article

A crucial role of constitutive androstane receptor (CAR) in liver tumor development by imazalil in mice.

The Journal of toxicological sciences - 1 Jan 2016

Tamura Kei, Inoue Kaoru, Takahashi Miwa, Matsuo Saori, Kodama Yukio, Yoshida Midori

Abstract excerpt

To clarify the major pathway of liver tumor development induced by imazalil (IMA), an imidazole fungicide, male constitutive androstane receptor (CAR)-knockout (CARKO) and wild-type (WT) mice were treated with IMA at 500 ppm in the diet up to 27 weeks after initiation by diethylnitrosamine. After 27 weeks of treatment, neither altered foci nor adenomas were significantly increased in CARKO mice, whereas both...

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Source

Identifiers

PMID: 27853109
DOI: 10.2131/jts.41.801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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