Article
Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver.
Biochemical and biophysical research communications - 25 Aug 2006
Guo Dongsheng, Sarkar Joy, Ahmed Mohamed R, Viswakarma Navin, Jia Yuzhi, Yu Songtao, Sambasiva Rao M, Reddy Janardan K
Abstract excerpt
The constitutive androstane receptor (CAR) regulates transcription of phenobarbital-inducible genes that encode xenobiotic-metabolizing enzymes in liver. CAR is localized to the hepatocyte cytoplasm but to be functional, it translocates into the nucleus in the presence of phenobarbital-like CAR l...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.