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Article

The increased CAR-dependent metabolism of thyroid hormones in mice with high cancer susceptibility.

Life sciences - 25 Sept 2010

Pakharukova Maria, Smetanina Mariya, Kaledin Vasily, Obut Timofey, Merkulova Tatiana

Abstract excerpt

AIM: our aim was to compare activation of the constitutive androstane receptor (CAR), hepatic expression of its target genes, and the serum thyroid hormone levels in C3H/He, C57BL/6J, and CC57BR/Mv mice following phenobarbital treatment. These differences, if present, could help to explain the different susceptibility to phenobarbital-induced liver tumor promotion among these strains of mice. MAIN METHODS: CAR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20816995
DOI: 10.1016/j.lfs.2010.08.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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