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Article

Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes.

The Journal of cell biology - 25 Oct 2004

Gottardi Cara J, Gumbiner Barry M

Abstract excerpt

Beta-catenin plays essential roles in both cell-cell adhesion and Wnt signal transduction, but what precisely controls beta-catenin targeting to cadherin adhesive complexes, or T-cell factor (TCF)-transcriptional complexes is less well understood. We show that during Wnt signaling, a form of beta-catenin is generated that binds TCF but not the cadherin cytoplasmic domain. The Wnt-stimulated, TCF-selective form is...

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Identifiers

PMID: 15492040
DOI: 10.1083/jcb.200402153
PMCID: PMC2172558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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