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Article

α-Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion.

The Journal of cell biology - 6 Nov 2017

Wood Megan N, Ishiyama Noboru, Singaram Indira, Chung Connie M, Flozak Annette S, Yemelyanov Alex, Ikura Mitsu, Cho Wonhwa, Gottardi Cara J

Abstract excerpt

A unique feature of α-catenin localized outside the cadherin-catenin complex is its capacity to form homodimers, but the subcellular localization and functions of this form of α-catenin remain incompletely understood. We identified a cadherin-free form of α-catenin that is recruited to the leading edge of migrating cells in a phosphatidylinositol 3-kinase-dependent manner. Surface plasmon resonance analysis shows...

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Identifiers

PMID: 28874417
DOI: 10.1083/jcb.201612006
PMCID: PMC5674881

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