Article
Probing transcription-specific outputs of β-catenin in vivo.
Genes & development - 15 Dec 2011
Valenta Tomas, Gay Max, Steiner Sarah, Draganova Kalina, Zemke Martina, Hoffmans Raymond, Cinelli Paolo, Aguet Michel, Sommer Lukas, Basler Konrad
Abstract excerpt
β-Catenin, apart from playing a cell-adhesive role, is a key nuclear effector of Wnt signaling. Based on activity assays in Drosophila, we generated mouse strains where the endogenous β-catenin protein is replaced by mutant forms, which retain the cell adhesion function but lack either or both of the N- and the C-terminal transcriptional outputs. The C-terminal activity is essential for mesoderm formation and...
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