Article
The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells.
Redox biology - 1 Oct 2016
Han Jingyan, Weisbrod Robert M, Shao Di, Watanabe Yosuke, Yin Xiaoyan, Bachschmid Markus M, Seta Francesca, Janssen-Heininger Yvonne M W, Matsui Reiko, Zang Mengwei, Hamburg Naomi M, Cohen Richard A
Abstract excerpt
BACKGROUND: Oxidative stress is implicated in increased vascular permeability associated with metabolic disorders, but the underlying redox mechanism is poorly defined. S-glutathionylation, a stable adduct of glutathione with protein sulfhydryl, is a reversible oxidative modification of protein and is emerging as an important redox signaling paradigm in cardiovascular physiopathology. The present study determines...
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