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Article

Cysteine-674 of the sarco/endoplasmic reticulum calcium ATPase is required for the inhibition of cell migration by nitric oxide.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2007

Ying Jia, Tong XiaoYong, Pimentel David R, Weisbrod Robert M, Trucillo Mario P, Adachi Takeshi, Cohen Richard A

Abstract excerpt

OBJECTIVES: Nitric oxide inhibits smooth muscle cell migration after arterial injury, but the detailed mechanism is not fully understood. The sarco/endoplasmic reticulum calcium ATPase (SERCA) lowers cell Ca2+ by increasing intracellular Ca2+ uptake and inhibiting extracellular Ca2+ influx. Our previous studies showed that NO causes cyclic GMP-independent arterial relaxation by increasing SERCA activity by...

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Source

Identifiers

PMID: 17234728
DOI: 10.1161/01.ATV.0000258413.72747.23

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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