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Enduring Reactive Oxygen Species Emission Causes Aberrant Protein S-Glutathionylation Transitioning Human Aortic Valve Cells from a Sclerotic to a Stenotic Phenotype.

Antioxidants & redox signaling - 1 Nov 2022

Valerio Vincenza, Keceli Gizem, Moschetta Donato, Porro Benedetta, Ciccarelli Michele, Massaiu Ilaria, Songia Paola, Maione Angela S, Alfieri Valentina, Myasoedova Veronika A, Zanobini Marco, Paolocci Nazareno, Poggio Paolo

Abstract excerpt

Aims: During calcific aortic valve stenosis (CAVS) progression, oxidative stress and endothelial dysfunction mark the initial pathogenic steps with a parallel dysregulation of the antioxidant systems. Here, we tested whether oxidation-induced protein S-glutathionylation (P-SSG) accounts for a phenotypic switch in human aortic valvular tissue, eventually leading to calcium deposition. Next, we tested whether...

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Identifiers

PMID: 35459416
DOI: 10.1089/ars.2021.0133
PMCID: PMC9689771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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