Article
S-glutathionylation uncouples eNOS and regulates its cellular and vascular function.
Nature - 23 Dec 2010
Chen Chun-An, Wang Tse-Yao, Varadharaj Saradhadevi, Reyes Levy A, Hemann Craig, Talukder M A Hassan, Chen Yeong-Renn, Druhan Lawrence J, Zweier Jay L
Abstract excerpt
Endothelial nitric oxide synthase (eNOS) is critical in the regulation of vascular function, and can generate both nitric oxide (NO) and superoxide (O(2)(•-)), which are key mediators of cellular signalling. In the presence of Ca(2+)/calmodulin, eNOS produces NO, endothelial-derived relaxing factor, from l-arginine (l-Arg) by means of electron transfer from NADPH through a flavin containing reductase domain to...
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