Article

Endothelial CYB5R3 couples store-operated calcium entry to TRPV2 activation and vascular fitness

2025-10-08

Abstract excerpt

<h4>ABSTRACT</h4> NADH–cytochrome b5 reductase 3 (CYB5R3) is a flavoprotein that governs nitric oxide (NO) signaling and supports NADPH oxidase 4–derived hydrogen peroxide production via coenzyme Q reduction in endothelium. While CYB5R3 expression is decreased during aging, the downstream consequences of CYB5R3 loss are not understood. Here, we demonstrate that depletion of CYB5R3 in primary human aortic endothel...

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Literature Corpus work: 896d9549-a6b8-582f-bf9c-e451e3ea3f9b
DOI: 10.1101/2025.10.08.681053

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