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Article

A role for AID in chromosome translocations between c-myc and the IgH variable region

27 Aug 2007

Abstract excerpt

Chromosome translocations between oncogenes and the region spanning the immunoglobulin (Ig) heavy chain (IgH) variable (V), diversity (D), and joining (J) gene segments (Ig V-J(H) region) are found in several mature B cell lymphomas in humans and mice. The breakpoints are frequently adjacent to the recombination signal sequences targeted by recombination activating genes 1 and 2 during antigen receptor assembly...

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PMID: 17724134
DOI: 10.1084/jem.20070884

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A role for AID in chromosome translocations between c-myc and the IgH variable regionPMID 17724134Read ↗

AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH TranslocationsSemantic proximity Read ↗

Haploinsufficiency of Activation-Induced Deaminase for Antibody Diversification and Chromosome Translocations both In Vitro and In VivoSemantic proximity Read ↗

Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc.Semantic proximity Read ↗

AID Binds Cooperatively with UNG and Msh2-Msh6 to Ig Switch Regions Dependent upon the AID C TerminusSemantic proximity Read ↗

AID expression levels determine the extent of <i>cMyc</i> oncogenic translocations and the incidence of B cell tumor developmentSemantic proximity Read ↗

BCL6 breaks occur at different AID sequence motifs in Ig–BCL6 and non-Ig–BCL6 rearrangementsSemantic proximity Read ↗

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.Semantic proximity Read ↗

The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombinationSemantic proximity Read ↗

Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.Semantic proximity Read ↗

Oncogenic events triggered by AID, the adverse effect of antibody diversificationSemantic proximity Read ↗

Role of the translocation partner in protection against AID-dependent chromosomal translocationsSemantic proximity Read ↗

AID-initiated DNA lesions are differentially processed in distinct B cell populations.Semantic proximity Read ↗

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