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Article

Switching on chromosomal translocations.

Cancer research - 15 Aug 2006

Ramiro Almudena R, Nussenzweig Michel C, Nussenzweig André

Abstract excerpt

Activation-induced deaminase initiates three different antibody diversification reactions: class switch recombination, somatic hypermutation (SHM), and gene conversion. We have shown that, in addition to antibody diversification, activation-induced deaminase can also initiate Burkitt's lymphoma-like c-myc/IgH translocations. However, distinct DNA damage- and oncogene-induced checkpoints operate in B cells to...

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Source

Identifiers

PMID: 16912154
DOI: 10.1158/0008-5472.CAN-06-0863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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