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Article

Uth1p: a yeast mitochondrial protein at the crossroads of stress, degradation and cell death

31 May 2004

Abstract excerpt

UTH1 is a yeast aging gene that has been identified on the basis of stress resistance and longer life span of mutants. It was also shown to participate in mitochondrial biogenesis. The absence of Uth1p was found to trigger resistance to autophagy induced by rapamycin. Uth1p is therefore the first mitochondrial protein proven to be required for the autophagic degradation of mitochondria. Since this protein is also...

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PMID: 15489196
DOI: 10.1016/j.femsyr.2004.05.001

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