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Article

Overexpression of human SOD1 in VDAC1-less yeast restores mitochondrial functionality modulating beta-barrel outer membrane protein genes.

Biochimica et biophysica acta - 1 Jun 2016

Magrì Andrea, Di Rosa Maria Carmela, Tomasello Marianna Flora, Guarino Francesca, Reina Simona, Messina Angela, De Pinto Vito

Abstract excerpt

Cu/Zn Superoxide Dismutase (SOD1), the most important antioxidant defense against ROS in eukaryotic cells, localizes in cytosol and intermembrane space of mitochondria (IMS). Several evidences show a SOD1 intersection with both fermentative and respiratory metabolism. The Voltage Dependent Anion Channel (VDAC) is the main pore-forming protein in the mitochondrial outer membrane (MOM), and is considered the...

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Source

Identifiers

PMID: 26947057
DOI: 10.1016/j.bbabio.2016.03.003

Genes

SOD1
VDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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